Lipid nanoparticles and non-viral carriers

Expand the possibilities of drug delivery with innovative analytical solutions for lipid raw materials, lipid nanoparticles (LNPs) and other non-viral carriers. Move beyond boundaries in structural elucidation and monitoring of analytes to estabilish confidence in the quality and stablity of your products.

Overview

Forge a new path to better lipid nanoparticle (LNP)-based gene therapies and vaccines with solutions for lipid structural elucidation that reach unprecedented depth and quantitation accuracy, precision and sensitivity.

Turn ionizable lipid N-oxidation, double-bond saturations and other lipid impurity challenges into opportunities. Join the team to rewrite the rules of lipid analysis with workflows looking beyond the known.

Perspectives:
  • "LNPs pose unique analytical challenges, in part due to the complexity of their lipid excipients. Consequently, the detailed structure elucidation capabilities afforded by electron activated dissociation (EAD) in the SCIEX ZenoTOF 7600 system provide the analytical chemist unparalleled capacity to identify problematic oxidative impurities inside ionizable lipids, and thereby de-risk the LNP therapeutic development process and expedite paths to the clinic."

    Adam Crowe, PhD Sr. Manager Analytical Development, Cytiva

Lipid structural elucidation

Workflow

Take your journey further with the ability to identify and quantify the lipid impurities present at well below 0.1% relative intensity. 

Workflows with novel fragmentation mechanisms overcome the limitations of traditional techniques, allowing full structural assessment of lipids and their impurities from raw materials and LNPs. Customizable, automated and data-driven solutions for lipid structural elucidation let you break free from the boundaries of drug formulation development.

  • Fully understand the structures of your ionizable lipids and impurities
  • Identify different oxygen incorporations, including N-oxides, saturated double bonds and more
  • Reclaim your time with automatic processing of complex data
  • Find relevant product excipients using state-of-the-art mass spectrometry solutions
  • Benefit from simultaneous quantitation capabilities

Solution

Lipid structural elucidation

Suited for:

  • In-depth structural elucidation
  • Relative quantitation
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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ZenoTOF 7600 system
A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.
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Molecule Profiler software
Determine impurities and biotransformations for a wide variety of modalities.
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Lipid impurity quantitation

Workflow

Take back your time with the ability to confirm and quantify hundreds of analytes in a streamlined manner. 

Monitoring known lipid impurities and other critical components in lipid raw materials and LNPs is easier than ever before. Take control with intuitive, highly sensitive and reliable solutions.

  • Achieve highly sensitive analyte detection independently of ionization polarity
  • Easily obtain comprehensive results using intuitive data processing solutions
  • Be confident with compliance-ready solutions that are robust and reliable

Solution

Lipid impurity quantitation

Suited for:

  • Monitoring of known lipid impurities
  • Superior sensitivity and robustness
ExionLC AE system
Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.
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SCIEX 7500 system
Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.
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SCIEX OS software
Unleash the analytical power of the next-generation software platform for data acquisition and processing.
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Associated applications

CRISPR/Cas9 analysis

Set your own schedule for CRISPR/Cas9 gene editing with innovative, intuitive analytical solutions. Unleash the potential of your Cas9 messenger RNA (mRNA), single guide RNA (sgRNA) and Cas9 proteins by understanding quality, purity and safety and assessing on/off target effects.

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Messenger RNA analysis

Break through barriers and extend the frontiers of messenger RNA (mRNA), self-amplifying RNA (saRNA) and circular RNA (circRNA) development with intuitive analytical solutions. Confidently innovate with high-quality, sensitive and accurate data to assess integrity, purity and critical quality attributes (CQAs).

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Synthetic oligonucleotide analysis

Work in pursuit of a higher level of quality for characterization of synthetic oligonucleotides—such as single guide RNA (sgRNA) or prime editing guide RNA (pegRNA)—used for CRISPR/Cas9 gene editing applications, along with antisense oligonucleotides (ASOs), small interfering RNA (siRNA) and aptamer therapeutics.

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